A STUDY COMPARING CEREBROSPINAL FLUID LACTATE LEVELS IN CHILDHOOD CULTURE POSITIVE AND CULTURE NEGATIVE MENINGITIS

author

  • M KEYHANI From the Dept. of Medical Biochemistry, Iran University of Medical Sciences, Tehran, I.R. Iran,
Abstract:

Despite recent innovations in the laboratory diagnosis of bacterial from nonbacterial meningitis, solid data-necessary for early determination of bacterial meningitis (BM) before organism growth in the culture medium-are missing. Therefore cerebrospinal fluid (CSF) lactate levels were evaluated as a possible means of differentiating the two clinical entities. This was a retrospective study. Patients were studied in one year. They were divided into three groups: Group one included 10 patients with culture positive meningitis Group two included 10 patients with culture negative meningitis compatible with a viral etiology Group three consisted of 10 febrile children without any biochemical or cytological CSF abnormality as the normal controls. CSF lactate level determinations were made enzymatically with Boehringer Mannheim reagents in addition to the formal biochemical and cytological investigations, consisting of cell counts and differential plus glucose and protein levels and CSF/blood glucose ratio in all three groups. Group one had a mean CSF lactate level of 12.90 (±3.08) mmol/L, while in groups 2 and 3 the level was 1.89 (± 0.52) mmoL/l and 1.63 (±0.31) mmol/L respectively. Lactate levels were significantly higher in patients from group one with respect to the control group (p= 0.001) whereas there were no significant differences between group 2 and the control group. Regarding temporal profile of CSF markers and considering the rapid rise in CSF lactate levels in bacterial meningitis, its measurement seems appealing to confirm a bacterial etiology instead of awaiting the results of CSF culture.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

a study comparing cerebrospinal fluid lactate levels in childhood culture positive and culture negative meningitis

despite recent innovations in the laboratory diagnosis of bacterial from nonbacterial meningitis, solid data-necessary for early determination of bacterial meningitis (bm) before organism growth in the culture medium-are missing. therefore cerebrospinal fluid (csf) lactate levels were evaluated as a possible means of differentiating the two clinical entities. this was a retrospective study. pat...

full text

False-negative cerebrospinal fluid cryptococcal latex agglutination tests for patients with culture-positive cryptococcal meningitis.

Three cases of false-negative cerebrospinal fluid latex agglutination test results for patients with culture-positive cryptococcal meningitis are reported. False-negative results occurred in settings of low cryptococcal antigen concentrations in cerebrospinal fluid and were dependent on the latex agglutination test kit used. Investigation of each case revealed that prozone phenomena or interfer...

full text

Estimation of Lactate Dehydrogenase Activity in cerebrospinal fluid in different types of meningitis

Objective: Meningitis is life-threatening condition and examination of the Cerebrospinal fluid (CSF) may not give a precise diagnosis and prognosis of different types of meningitis. Bacterial meningitis is still a very common problem especially in many developing countries. The aims of study are to estimate the importance and significance of Lactate Dehydrogenase (LDH), protein...

full text

Estimation of Lactate Dehydrogenase Activity in cerebrospinal fluid in different types of meningitis

Objective: Meningitis is life-threatening condition and examination of the Cerebrospinal fluid (CSF) may not give a precise diagnosis and prognosis of different types of meningitis. Bacterial meningitis is still a very common problem especially in many developing countries. The aims of study are to estimate the importance and significance of Lactate Dehydrogenase (LDH), protein...

full text

c-reactive protein and lactate dehydrogenase in serum and cerebrospinal fluid in rapid and early diagnosis of childhood meningitis

objective bacterial meningitis is still a life threatening epidemiological problem especially in many developing countries; considering its dire consequences, its prompt and accurate diagnosis has become a priority for clinicians. because of the various limitations of conventionally used laboratory techniques, we evaluated and compared the diagnostic utility of c-reactive protein(crp) and lacta...

full text

CEREBROSPINAL FLUID FINDINGS IN NEONATAL BACTERIAL MENINGITIS

Background : Meningitis is more common during the neonatal period than other periods of life and has a prevalence of one in 1000 live births. The similarity of its clinical manifestations with other infectious diseases makes it difficult to diagnose. The aim of the current study was to determine the relationship between age, sex, clinical signs and symptoms and laboratory test results of ne...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 17  issue 1

pages  29- 34

publication date 2003-05

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023